LR III powder

LR III powder, the ingredient of LUNWAN tablet, has been produced from dried powder of earthworm in Kiryu Co., Ltd. (Miyazaki, Japan) since the beginning, 16 years ago. Kiryu Co. Ltd. has only one manufacturing patent in Japan (Japanese Patent No. 4808822) together with other international patents, and has investigated, bred, and produced powder of earthworm since 1976.

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Factory tour in Kiryu Co. June 4, 2012

Manufacturing process of LR III powder

Cultivation & Breeding

Conventional cultivation system of earthworm was very difficult to manage cultivation of earthworm and be adapted for environmental changes in climate. In addition, we couldn’t expand scale of cultivation because outside earthworm is easy to be attacked and escape during raining. After that, we’d solved problems derived from wind and rain by cultivation in a plastic greenhouse. However temperature in the house would be too high in summer season (due to long exposure of sunlight although proper sunlight is no problem), leading to loss of earthworm although we expected increase amount of earthworm.
Now cultivation is performed in wooden box in the high ceiling house for prevention of sunlight, so that water content and temperature in the soil is well controlled by breathing by wood itself and current cultivation technique, leading that situation in the cultivation is more similar to nature. Our cultivation system is also easily transferable to anywhere, inside or outside of cultivation house, for controlling ventilation and sunlight depending on growth of earthworm.
In addition, we can manage cultivation by the one wooden box without any harmful effects to others even though cultivation situation is getting worse in one box, leading that current circumstances in the cultivation earthworm improves tremendously.
Even now our research about cultivation of earthworm is ongoing. To make a satisfied product with customers, we do our best in a spirit of comfort, safe, and stable supply.

Soil Shipping

Inspection of soil
We examine condition of soil for cultivation, so that the results utilize controlling cultivation of earthworm and research & development of earthworm.

Shipping from soil
We ship earthworm which is taken out from the cultivation box on the day before shipping.

Sampling survey
We perform quality check by sampling survey of shipped earthworm.

Shipping from soil
We take an advantage of earthworm’s feature, “nocturnal behavior (escape from light)” for shipping. We take off small soil from the top of cultivation box gradually. Then earthworm go into deeper and deeper in response to the light. Then, once earthworm finally reach to the bottom of concrete floor, we transfer gathered them into a shipping box (a plastic box). After that, we also spend more time to be excluded feces and soil from earthworm, then measure amount of them.

This is a conventional way to ship by using earthworm’s feature which are very useful in many processes including cultivation.

Cleaning

Cleagning
Feces, soil and other impurities in and on the body are exclude by the treatment with citric acid and others. After that, earthworm is slowly and repeatedly washed by microbubbled water. At this process, we extreme-carefully handle not to harm because active ingredient will be reduced once earthworm has damage during the process. We also survey by visual examination of sampling after cleaning.

What is microbubble? ????Bubbles in the water with the size of 500µm (0.5mm) or less

Freezing Drying

Freezing in the special plates
Paste of cleaned earthworm is frozen immediately after transfer into a special tray which is considered depending on material and size. This process let active ingredients become ibernating state.

Drying in vacuum freeze dryer
Contained water is gradually evaporated by vacuum freeze drying for 45 hours (2 days). During the process, impurities which prevent active ingredients are also removed along with water, so that the product would be higher quality freeze-dry earthworm powder. In the patented drying process, hibernating state of the product will last until active ingredients contact water

Powderization

Grinding operation
Dried earthworm by vacuum freeze dryer is grinded into powder. We also survey quality of samples in this process

Sterilizing operation
Sterilization is also performed during this process although freeze dry has also sterilizing effect. We also survey quality of samples in this process, so that powder will be finally a commercial product after pass sample inspection. Therefore a commercial product will be more comfortable and safe though this process.

Shipping
Contained water is gradually evaporated by vacuum freeze drying for 45 hours (2 days). During the process, impurities which prevent actions of active ingredients are also removed along with water, so that the product would be higher quality freeze-dry earthworm powder. A quality approved powder will be sealed and then be shipped into the market.

Shipping of products

Commercializing of dried earthworm powder LR III
The factory for final commercialization is certified according to GMP of Japan Health Food & Nutrition Food Association, and ISO-14001, a standard of quality management.
The quality and safety of product is guaranteed by establishing appropriate management system and operation management (quality management, manufacturing management) (GMP soft), and establishing appropriate buildings and facilities (GMP hard) during the moment of receiving row materials to that of shipping final products.

GMP
GMP is an abbreviation for Good Manufacturing Practice, which means an appropriate standard for manufacturing.

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Examination of raw material at receiving

We only use freeze dry powder of earthworm (LR III powder) from Kiryu Co., which pass an acceptance examination,

Tableting Filling

Mixed powder manufactured through the previous process is tableting and filling to be a final product.

The third generation of LR III powder

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LR powder (first generation), which is commercialized in 1990s, is developed into second generation and third generation.

LR III powder (third generation) is a product that contain more enzyme compared to previous one by removing inactive ingredients (inhibitor of fibrinolytic enzyme, ammonia, heavy metal, etc) as much as possible. Therefore enzymatic activity is increased and smell are substantially reduced, leading that it is easy to be taken compared to previous one.

Authenticated sticker of LR III powder

“Authenticated sticker” is put on the package of product which is contained LR III powder.

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List of Granted patents of LR III powder

Granted patents of LR III powderIncluding previously granted patents Utility patent number: No.2015873 (February 19, 1996)
Utility patent number: No.2059972 (June 10, 1996)
Utility patent number: No.2059973 (June 10, 1996)
Manufacturing method of previous LR powder
Process patent number : No.2090412 (September 18, 1996)
Process patent number : No.3037355 (February 25, 2000)
Manufacturing method of LR powder (titer is double compared to previous LR powder)Process patent number : No.4699974 (March 11, 2011)
Manufacturing method of LR powder (titer is four times compared to previous LR powder)Process patent number : No.4808822 (August 26, 2011)
Manufacturing method of LR III powder (no negative effect on active ingredient after heating)Process patent number : No.4886017 (December 16, 2011)

Japanese Patent License

Inventor Kazuyuki ISHII (Kiryu Co. Ltd.)
Co-inventor Yoichi ISHI Chairman (Kiryu Co. Ltd.)
Professor Hiroyuki Sumi (Kurashiki University of Science and the Arts)

LR III powder (Dried earthworm powder)
Manufacturing method
Country where we granted patents

Japan No.4808822
Korea No.10-1198192
China No.1228591
Australia No.2011338109
Taiwan No. I 376226
Canada No.280412
EU countries (Belgium, Germany, Denmark, Spain, France, United Kingdom, Hungary, Italia, Monaco, Netherland)

(Others Appling patent)
United States of America, Hong Kong, Russia Brazil, India, Philippine, Israel)

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LR III powder (dried earthworm powder)

LR III powder

Description

LR III powder, the ingredient of LR powder-related products, has been produced from dried powder of earthworm in Kiryu Co., Ltd. (Miyazaki, Japan) since the beginning of launching, 16 years ago. Kiryu Co. has only one manufacturing patent in Japan (Japanese Patent # 4808822, also granted international patents), and has investigated, bred, and earthworm related products since 1976.

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Contact of products

Synapse Co., Ltd.
Head office 3-29-13 Kengun, Higashi-ku, Kumamoto city, Kumamoto, 862-0911
Phone: +8196-288-9887 FAX: +8196-288-9938

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